Many Notre Dame alumni have found success on the professional level. Over the last 25 years, 40 professional baseball players have developed while playing for Dill. Some notable alumni in Minor/Major League Baseball include:

- Giancarlo Stanton, New York Yankees, 4-time All-Star, NL MVP, NL home run leader (active)
- Hunter Greene, Dayton Dragons under Cincinnati Reds, second overall selection in 2017 MLB Draft (active)
- Kelly Dugan, Chicago Dogs
- Josh Goossen-Brown, Chicago Dogs
- JJ Muno, Winston-Salem Dash under Chicago White Sox (active)
- Tommy Wilson, St. Lucie Mets under New York Mets (active)
- David Armendariz, Lake County Captains under Cleveland Indians
- Eddie Muhl, Bristol Pirates under Pittsburgh Pirates
- Tim Foli (first round draft-pick 1969, World Series Champ)
- Greg Goossen (Multiple teams)
- Chris Dickerson (Multiple Teams)
- Brett Hayes, Texas Rangers
- Brendan Ryan (Multiple Teams)
- Jack McDowell (1993 Cy Young Award winner)
- Jorge Piedra, Colorado Rockies
- Tom Gamboa, Coach (Multiple Teams)
- Bobby Hughes, Milwaukee Brewers
- Pat Gillick, 2-time World Series GM (MLB Hall of Fame)